330 Background: We evaluated whether the intermediate-risk factors of percentage of positive biopsies (PPB), clinical tumor category, and prostate-specific antigen (PSA) level, in addition to age, were associated with the risk of prostate cancer-specific mortality (PCSM) among men with Gleason 3+4 prostate cancer treated with brachytherapy (BT) alone or BT and a short course of androgen Despite the presence usual acinar adenocarcinoma of both Gleason pattern 3 and Gleason pattern 4 morphologies, 50% of the entire tumor was composed of a pseudohyperplastic component with peculiar, inverted polarity (Figs. 1 and 2). In these areas, almost all nuclei were arranged away from the basement membrane and located close to glandular lumina. Based on a biopsy sample, having a Gleason score of 8–10 could indicate a risk of cancer spreading from the prostate to other parts of the body. Prostate-specific antigen (PSA) blood tests Download scientific diagram | Small cell carcinoma in close association with Gleason 4+3 acinar adenocarcinoma (same case as Figure-4). Hematoxilin-eosin, 100x. from publication: Prostatic Patients with IDC-P at biopsy or radical prostatectomy are more likely to have higher Gleason grade acinar adenocarcinoma, more advanced pathological stage, and worse clinical features, such as Ductal and acinar prostate adenocarcinoma components of mixed tumors most often share the same origin and are clonally related. DA components in mixed tumor often exhibit genome doubling events resulting in aneuploidy, consistent with the aggressive nature of high grade prostate cancer. Case description: We report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3+3=6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and Acinar adenocarcinoma of the prostate (ACP) accounts for more than 90% of primary prostate cancer (PCa) cases, and the second most common histological PCa subtype is ductal adenocarcinoma (DCP) . DCP is characterized by tall columnar cells arranged in a cribriform, papillary, solid pattern similar to prostatic intraepithelial neoplasia .
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    • adenocarcinoma acinar usual gleason 3 4